changes in cerebral perfusion detected by dynamic susceptibility contrast magnetic resonance imaging normal volunteers examined during normal breathing and hyperventilation脑灌注的变化检测到动态敏感性对比磁共振成像正常志愿者检查在正常呼吸和换气过度.pdfVIP

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changes in cerebral perfusion detected by dynamic susceptibility contrast magnetic resonance imaging normal volunteers examined during normal breathing and hyperventilation脑灌注的变化检测到动态敏感性对比磁共振成像正常志愿者检查在正常呼吸和换气过度.pdf

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changes in cerebral perfusion detected by dynamic susceptibility contrast magnetic resonance imaging normal volunteers examined during normal breathing and hyperventilation脑灌注的变化检测到动态敏感性对比磁共振成像正常志愿者检查在正常呼吸和换气过度

J. Biomedical Science and Engineering, 2009, 2, 210-215 JBiSE doi: 10.4236/jbise.2009.24034 Published Online August 2009 (http://www.SciRP.org/journal/jbise/). Changes in cerebral perfusion detected by dynamic susceptibility contrast magnetic resonance imaging: normal volunteers examined during normal breathing and hyperventilation Ronnie Wirestam1* 2 3 4 1,4 2 , Christian Engvall , Erik Ryding , Stig Holtås , Freddy Ståhlberg , Peter Reinstrup 1Department of Medical Radiation Physics, Lund University, Lund, Sweden; 2Department of Anaesthesiology Intensive Care, Lund University Hospital, Lund, Sweden; 3Department of Clinical Neurophysiology, Lund University Hospital, Lund, Sweden; 4Department of Diagnostic Radiology, Lund University, Lund, Sweden. Email: Ronnie.Wirestam@med.lu.se Received 3 March 2009; revised 2 April 2009; accepted 24 April 2009. ABSTRACT arterial signal saturation [3] and local geometrical distor- tion [4] at peak concentration, as well as by partial- Global cerebral perfusion parameters were volume effects [5]. Furthermore, the T2* relaxivities of measured using dynamic susceptibility contrast the paramagnetic contrast agent are, most likely, differ- magnetic resonance imaging (DSC-MRI) in eight ent in arterial and tissue environments, and the non-lin- healthy volunteers examined during normal ear relationship in whole blood between transversal re- breathing an