characteristics of suppressor macrophages induced by mycobacterial and protozoal infections in relation to alternatively activated m2 macrophages分枝杆菌引起的抑制巨噬细胞和原生动物的感染特点与另外m2巨噬细胞激活.pdfVIP

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characteristics of suppressor macrophages induced by mycobacterial and protozoal infections in relation to alternatively activated m2 macrophages分枝杆菌引起的抑制巨噬细胞和原生动物的感染特点与另外m2巨噬细胞激活.pdf

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characteristics of suppressor macrophages induced by mycobacterial and protozoal infections in relation to alternatively activated m2 macrophages分枝杆菌引起的抑制巨噬细胞和原生动物的感染特点与另外m2巨噬细胞激活

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 635451, 19 pages doi:10.1155/2012/635451 Review Article Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages Haruaki Tomioka,1 Yutaka Tatano,1 Win Win Maw,1 Chiaki Sano,1 Yuichi Kanehiro,1 and Toshiaki Shimizu2 1 Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, Japan 2 Department of Nutritional Sciences, Faculty of Home Economics, Yasuda Women’s University, Hiroshima 731-0153, Japan Correspondence should be addressed to Haruaki Tomioka, tomioka@med.shimane-u.ac.jp Received 21 December 2011; Revised 22 February 2012; Accepted 23 February 2012 Academic Editor: Nejat Egilmez Copyright © 2012 Haruaki Tomioka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In the advanced stages of mycobacterial infections, host immune systems tend to change from a Th1-type to Th2-type immune response, resulting in the abrogation of Th1 cell- and macrophage-mediated antimicrobial host protective immunity. Notably, this type of immune conversion is occasionally associated with the generation of certain types of suppressor macrophage populations. During the course of Mycobacterium tuberculosis (MTB) and Mycobacterium avium-intracellulare complex (MAC) infections, the generation of macrophages which possess strong suppressor activity against host T- and B-cell functions is frequently encountered. This paper describes the immunological properties of M1- and M2-type macropha