原创力文档computer-assisted analysis of subcellular localization signals and post-translational modifications of human prion proteins计算机辅助分析人类朊病毒蛋白质的亚细胞定位信号和转录后修饰.pdfVIP
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computer-assisted analysis of subcellular localization signals and post-translational modifications of human prion proteins计算机辅助分析人类朊病毒蛋白质的亚细胞定位信号和转录后修饰
J. Biomedical Science and Engineering, 2009, 2, 70-75 1
Computer-Assisted analysis of subcellular
localization signals and post-translational
modifications of human prion proteins
Fatemeh Moosawi, Hassan Mohabatkar*
Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran, *Corresponding author to Fatemeh Moosawi (mohabat@shirazu.ac.ir), Telephone:
+98711-6137426, Mobile: 09177157459, Fax: +98711-2280926.
Received August 26th, 2008; revised December 19th, 2008; accepted December 7th, 2008
ABSTRACT into an insoluble form (PrPsc) [4].
Prions are devoid of nucleic acid and seem to be com-
In the present work, computational analyses posed exclusively of protein. The normal, cellular PrP is
were applied to study the subcellular localiza- converted into PrPsc through a process whereby a por-
tion and posttranslational modifications of hu- tion of its α-helical and coil structure is refolded into
man prion proteins (PrPs). The tentative location β-sheet [5,6]. This structural transition is accompanied
of prion protein was determined to be in the nu- by profound changes in the physicochemical properties
cleolus inside the nucleus by the following bio- of the PrP [7]. At the molecular level, PrP is a sialogly-
9 informatics tools: Hum-PLoc, Euk-PLoc and coprotein of 253 amino acids in human [8]. The
0 Nuc-PLoc. Based on
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