determination of inter- and intra-subtypespecies varia-tions in polymerase acidic protein from influenza a virus using amino-acid pair predictability国米和测定intra-subtypespecies varia-tions从甲型流感病毒聚合酶酸性蛋白质使用氨基酸对可预测性.pdfVIP

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determination of inter- and intra-subtypespecies varia-tions in polymerase acidic protein from influenza a virus using amino-acid pair predictability国米和测定intra-subtypespecies varia-tions从甲型流感病毒聚合酶酸性蛋白质使用氨基酸对可预测性.pdf

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determination of inter- and intra-subtypespecies varia-tions in polymerase acidic protein from influenza a virus using amino-acid pair predictability国米和测定intra-subtypespecies varia-tions从甲型流感病毒聚合酶酸性蛋白质使用氨基酸对可预测性

J. Biomedical Science and Engineering, 2009, 2, 273-279 JBiSE doi: 10.4236/jbise.2009.24041 Published Online August 2009 (http://www.SciRP.org/journal/jbise/). Determination of inter- and intra-subtype/species varia- tions in polymerase acidic protein from influenza A virus using amino-acid pair predictability Shaomin Yan1 2 , Guang Wu * 1 National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, 98 Daling Road, Nanning, Guangxi, 530007, China; 2Computational Mutation Project, DreamSciTech Consulting, 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province 518054, China. Email: hongguanglishibahao@ Received 23 March 2009; revised 15 April 2009; accepted 28 April 2009. ABSTRACT Currently, the manufactured vaccines are designed to target the influenza A virus according to their subtypes, The polymerase acidic protein is an important for example, the focus in recent year would be the H5N1 family of proteins from influenza A virus, which subtype of influenza A virus [7,8,9,10,11,12,13,14], and is classified as many different subtypes or spe- anti-flu drugs are designed to target neuraminidases and cies. Thus, an important question is if these M2 protein [15,16]. It would be understandable that classifications are numerically distinguishable proteins should be different from one subtype to another. with respect to the polymerase acidic protein. Otherwise, there would be no classification of subtype. The amino-acid pair predict