effect of flunixin meglumine alone and in combination on haemodynamics during bovine endotoxic shock and after treatment氟尼辛葡甲胺单独和组合对血液动力学的影响在牛内毒素休克和治疗后.pdfVIP

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effect of flunixin meglumine alone and in combination on haemodynamics during bovine endotoxic shock and after treatment氟尼辛葡甲胺单独和组合对血液动力学的影响在牛内毒素休克和治疗后.pdf

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effect of flunixin meglumine alone and in combination on haemodynamics during bovine endotoxic shock and after treatment氟尼辛葡甲胺单独和组合对血液动力学的影响在牛内毒素休克和治疗后

J. Biomedical Science and Engineering, 2011, 4, 29-33 JBiSE doi:10.4236/jbise.2011.41004 Published Online January 2011 (http://www.SciRP.org/journal/jbise/). Effect of flunixin meglumine alone and in combination on haemodynamics during bovine endotoxic shock and after treatment Digvijay Singh, Satish Kumar Bansal, Gurbrinderjit Singh Ghumman Department of Veterinary Physiology Biochemistry, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sci- ences University, Ludhiana, India. Email: digvijay231@ Received 21 July 2010; revised 26 August 2010; accepted 30 August 2010. ABSTRACT Keywords: Buffalo Calves; Flunixin Meglumine; Haemodynamics; Hypertonic Saline; Endotoxic Shock To investigate the effect of Flunixin meglumine- a NSAID; alone and in combination with hypertonic 1. INTRODUCTION saline on endotoxemic buffalo calves, two groups of Endotoxemia is a potentially devastating complication of five apparently healthy male buffalo calves aged be- several diseases of cattle e.g. enteric disease, septicemia, tween 6-8 months were subjected to I.V. infusion of metritis, mastitis and pneumonia [1]. Endotoxemia is a E.coli endotoxin at the rate of 5μg/kg BW per hour life threatening inflammatory condition which can lead for 3 hours. A highly significant (P 0.01) fall in