effects of growth hormone and insulin-like growth factor-1 on postoperative muscle and substrate metabolism生长激素和胰岛素样生长因子- 1在术后肌肉和基质代谢.pdfVIP

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effects of growth hormone and insulin-like growth factor-1 on postoperative muscle and substrate metabolism生长激素和胰岛素样生长因子- 1在术后肌肉和基质代谢.pdf

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effects of growth hormone and insulin-like growth factor-1 on postoperative muscle and substrate metabolism生长激素和胰岛素样生长因子- 1在术后肌肉和基质代谢

Hindawi Publishing Corporation Journal of Nutrition and Metabolism Volume 2010, Article ID 647929, 9 pages doi:10.1155/2010/647929 Clinical Study Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Postoperative Muscle and Substrate Metabolism 1, 2 ¨ 3 2, 4 Folke Hammarqvist, Ingmar Wennstrom, and Jan Wernerman 1 Gastrocentrum, Karolinska University Hospital Huddinge, K53, S-141 86 Stockholm, Sweden 2 CLINTEC (Institute of Clinical Science Intervention and Technology), The Karolinska Institutet, S-141 86 Stockholm, Sweden 3 Scandinavian Venous Centre, S-113 32 Stockholm, Sweden 4 Department of Anaesthesia and Intensive Care, Karolinska University Hospital Huddinge, B-32, S-141 86 Stockholm, Sweden Correspondence should be addressed to Folke Hammarqvist, folke.hammarqvist@ki.se Received 22 May 2009; Revised 27 September 2009; Accepted 2 November 2009 Academic Editor: Thomas R. Ziegler Copyright © 2010 Folke Hammarqvist et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This study explored if a combined supplementation of GH and IGF-1 had an additive eﬀect on whole body nitrogen economy, energy, substrate and skeletal muscle metabolism following surgical trauma. Patients were randomized to controls (C; n = 10), to GH (0.15 IU/kg/injection) (GH; n = 7) or GH combined with IGF-1 (40 μg/kg/injection) subcutaneously twice a day (GH-IGF-1; n = 9) together with standardized parenteral nutrition. Muscle amino acids, glutathione and the ribosomal pattern r