原创力文档effects of serum from a fibrodysplasia ossificans progressiva patient on osteoblastic cells血清的影响从fibrodysplasia ossificans progressiva病人对成骨细胞的细胞.pdfVIP
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effects of serum from a fibrodysplasia ossificans progressiva patient on osteoblastic cells血清的影响从fibrodysplasia ossificans progressiva病人对成骨细胞的细胞
Open Journal of Endocrine and Metabolic Diseases, 2012, 2, 1-6
/10.4236/ojemd.2012.21001 Published Online February 2012 (http://www.SciRP.org/journal/ojemd)
Effects of Serum from a Fibrodysplasia Ossificans
Progressiva Patient on Osteoblastic Cells
1 2 3 4 1,5,6*
Itoko Hisa , Akira Kawara , Takenobu Katagiri , Toshitsugu Sugimoto , Hiroshi Kaji
1Division of Diabetes and Endocrinology, Department of Internal Medicine,
Kobe University Graduate School of Medicine, Kobe, Japan
2Kawara Clinic, Kobe, Japan
3Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, Japan
4Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan
5Division of Cellular and Molecular Medicine, Department of Physiology and Cellular Biology,
Kobe University Graduate School of Medicine, Kobe, Japan
6Department of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine, Osaka, Japan
*
Email: hkaji@med.kindai.ac.jp
Received 5 December 2011; revised 1 January 2012; accepted 30 January 2012
ABSTRACT
Introduction: Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder of skeletal malforma-
tions and progressive extraskeletal ossification. Patients and Methods: In the present study, we present a case of FOP
with marked progressive ossification of extraskeletal tissues. We investigated whether soluble factors in serum would
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