原创力文档efficacy and tolerability of candesartan cilexetil and amlodipine in patients with poorly controlled essential hypertension坎地沙坦的疗效和耐受性cilexetil和氨氯地平差控制的原发性高血压患者.pdfVIP
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efficacy and tolerability of candesartan cilexetil and amlodipine in patients with poorly controlled essential hypertension坎地沙坦的疗效和耐受性cilexetil和氨氯地平差控制的原发性高血压患者
International Journal of Clinical Medicine, 2011, 2, 64-68
doi:10.4236/ijcm.2011.22012 Published Online May 2011 (http://www.SciRP.org/journal/ijcm)
Efficacy and Tolerability of Candesartan Cilexetil
and Amlodipine in Patients with Poorly Controlled
Essential Hypertension
—Efficacy of Candesartan and Amlodipine
Kazuaki Nishio, Takeshi Kondo, Youichi Kobayashi
The Third Department of Internal Medicine, School of Medicine, Showa University, Tokyo, Japan.
Email: kazukun@jg7.so-net.ne.jp
Received August 13th, 2010; revised January 7th, 2011; accepted January 15th, 2011.
ABSTRACT
Current treatment guidelines for hypertension in both Europe and the USA stress the importance of aggressive blood
pressure control . When monotherapy is not enough to reach treatment targets, there is a need for combination regimens
that have both high efficacy and good tolerability. The aim of this study is to evaluate the efficacy and tolerability of the
combination therapy candesartan and amlodipine in patients with hypertension not satisfactorily controlled by mono-
therapy. Patients with uncomplicated essential hypertension not satisfactorily controlled by monotherapy, which is
candesartan 8 mg or amlodipine 5 mg, were eligible. Candesartan 8 mg and amlodipine 5 mg were given for 12 weeks.
13 patients who received candesartan 8 mg previoursly were assigned to the candesartan group and 8 patients who
received amlodipine 5 mg previoursly were assigned to the amlodipine group. Sitting systolic blood pressure (SBP) at
baseline was 151.9 ± 11.6 mmHg in the candesartan group, and 154.6 ± 7.6 mmHg in the amlodipine group. Sitting
diastolic blood pressure (DBP) was 93.2 ± 13.1 in the candesartan group, and 80.4 ± 14.7 in the amlodipine group.
DBP in the amlodipine group was lower than that in the cadesartan group (P = 0.036). After the combination therapy,
SBP was significantly reduced in the two groups. DBP showed significant reduction in th
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