原创力文档efficacy and safety of sunitinib in japanese patients with metastatic renal cell carcinoma疗效和安全性的舒尼替日本转移性肾细胞癌患者.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
efficacy and safety of sunitinib in japanese patients with metastatic renal cell carcinoma疗效和安全性的舒尼替日本转移性肾细胞癌患者
Journal of Cancer Therapy, 2011, 2, 335-341 335
doi:10.4236/jct.2011.23046 Published Online August 2011 (http://www.SciRP.org/journal/jct)
Efficacy and Safety of Sunitinib in Japanese
Patients with Metastatic Renal Cell Carcinoma
——Sunitinib for Japanese Patients Financial Disclosures: None
Takahito Suyama1 2 2 2 2
, Takeshi Ueda , Satoshi Fukasawa , Atsushi Komaru , Masayuki Kobayashi ,
Yukio Naya1 1 1
, Naoki Nihei , Tomohiko Ichikawa
1Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan; 2Prostate Center and Division of Urology,
Chiba Cancer Center, Chiba, Japan.
Email: urolccc@yahoo.co.jp
Received April 10th, 2011; revised June 16th, 2011; accepted June 23rd, 2011.
ABSTRACT
Objective: This study aim to assess the efficacy and safety of sunitinib in Japanese patients with metastatic renal cell
carcinoma (mRCC) in general clinical practice. Patients and Methods : Non-selected fifty eight Japanese patients with
mRCC were treated with sunitinib. Overall survival (OS) and time to treatment failure (TTF) were estimated. Response
rate and safety profiles were also assessed. Results : Partial response, stable disease, and progressive disease were
observed in 13 (22.4%), 26 (44.8%), and 19 (32.8%) patients , respectively. The median TTF was 5.4 months, and the
median OS was 11.2 months. In the prior nephrectomy group, the median TTF was 9.0 months, and the median OS was
16.4 months. In the non-nephrectomy group, the median TTF was 1.1 months, and the median OS was 2.8 months. The
most frequently occurring Grade 3/4 adverse events (AEs) were anorexia (17.2%), fatigue (12.1%), thrombocytopenia
(13.8%), and anemi
您可能关注的文档
- effects of 16-week consumption of caffeinated and decaffeinated instant coffee on glucose metabolism in a randomized controlled trial16周的影响食用含咖啡因和不含咖啡因的咖啡,在葡萄糖代谢的随机对照试验.pdf
- effectiveness of sub-maximal intermittent exercise on muscle glycogen depletion, pgc-1α and pdk-4 gene expression的有效性sub-maximal间歇运动对肌肉糖原耗竭,pgc-1αpdk-4基因表达.pdf
- effects of a combination of thyme and oregano essential oils on tnbs-induced colitis in mice百里香和牛至精油的效果在老鼠tnbs-induced结肠炎.pdf
- effects of air pollutants on development of allergic immune responses in the respiratory tract空气污染对发展的影响呼吸道过敏免疫反应.pdf
- effects of a cereal and soy dietary formula on rehabilitation of undernourished children at ouagadougou, in burkina faso影响康复的谷物和大豆膳食配方营养不良儿童在瓦加杜古布基纳法索.pdf
- effects of autoclaving on the physiological action of paclobutrazol高压灭菌法对摘要的生理作用的影响.pdf
- effects of baking, roasting and frying on total polyphenols and antioxidant activity in colored chickpea seeds烘焙、烧烤和油炸的总多酚和抗氧化活性有色鹰嘴豆种子.pdf
- effects of aquajogging in obese adults a pilot studyaquajogging肥胖成年人一个试点研究的影响.pdf
- effects of a low-voltage electric pulse charged to culture soil on plant growth and variations of the bacterial community低压电气脉冲充电的影响文化土壤细菌群落的植物生长和变化.pdf
- effects of artificial flooding for hydroelectric development on the population of mansonia humeralis (diptera culicidae) in the paraná river, s？o paulo, brazil水电开发人造洪水影响的人口mansonia humeralis(双翅目蚊科)巴拉那河,s 圣保罗,巴西.pdf
- efficacy and toxicity of metronomic capecitabine in advanced hepatocellular carcinoma月复一月的疗效和毒性卡培他滨在先进的肝细胞癌.pdf
- efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis a randomized, double-blind three-arm dose finding study疗效和耐受性的蜂胶特殊提取gh 2002作为随机对口唇疱疹的唇膏,双盲三臂剂量发现研究.pdf
- efficacy and safety of low-dose everolimus as maintenance immunosuppression in cardiac transplant recipients疗效和安全性的低剂量everolimus维护心脏移植受者的免疫抑制.pdf
- efficacy of an abduction brace in preventing initial dislocation in the early postoperative period after primary total hip arthroplasty功效的绑架撑在预防术后早期的初始位错的初次全髋置换术后.pdf
- efficacy of 1-(n-acetyl-6-aminohexyl)-3-hydroxypyridin-4-one (cm1) in treatment of iron-loaded hepatocyte cultures的功效1 -(n-acetyl-6-aminohexyl)3-hydroxypyridin-4-one(cm1)治疗iron-loaded肝细胞的文化.pdf
- efficacy and tolerance study of an oligopeptide with potential anti-aging activity疗效和耐受性的研究与潜在的抗衰老活性寡肽.pdf
- efficacy and safety of low-dose cyclosporine with everolimus and steroids in de novo heart transplant patients a multicentre, randomized trial低剂量环孢霉素的临床疗效和安全性everolimus和类固醇新创心脏移植患者的多中心,随机试验.pdf
- efficacy and tolerability of a combined moxifloxacindexamethasone formulation for topical prophylaxis in phacoemulsification an open-label single-arm clinical trial疗效和耐受性的超声乳化吸出术联合moxifloxacindexamethasone制定预防局部的非盲单臂的临床试验.pdf
- efficacy of a synbiotic chewable tablet in the prevention of antibiotic-associated diarrhea预防的功效的synbiotic咀嚼片antibiotic-associated腹泻.pdf
- efficacy of imod in the treatment of oral lichen planus—efficacy of imod in oral lichen planusimod的功效治疗口腔苔藓planus-efficacy imod的口腔扁平苔癣.pdf
文档评论（0）