黄体酮治疗煤工尘肺肺心病临床探究.docVIP

黄体酮治疗煤工尘肺肺心病临床探究作者单位：277519 山东省枣庄矿业集团滕南医院（商云逸，王秀）；山东省微湖监狱医院（胡海波） 通讯作者：商云逸 【摘要】 目的 观察黄体酮治疗煤工尘肺（CWP）肺心病的临床疗效及安全性。方法 96例CWP肺心病患者随机分成三组：合并呼吸衰竭黄体酮治疗组、合并呼吸衰竭基础治疗组和不合并呼吸衰竭黄体酮治疗组，对比三组间、不同尘肺期别治疗前后血气、肺功能变化，观察不良反应。结果 CWP肺心病合并呼吸衰竭患者黄体酮治疗后PaO2明显升高（P0.05）。Ⅰ、Ⅱ期尘肺黄体酮治疗后血气和肺功能改善较Ⅲ期尘肺明显。结论 黄体酮治疗CWP肺心病安全有效，可显著改善煤工尘肺肺心病尤其合并呼吸衰竭患者的血气及肺功能，对Ⅰ期、Ⅱ期尘肺疗效优于Ⅲ期尘肺。 【关键词】 尘肺； 黄体酮； 肺心病； 呼吸衰竭 Clinical study on progesterone treatment of coal worker’s Peumoconiosis Cor pulmonale SHANG Yun-yi*,HU Hai-bo,WANG Xiu*.Tengna Hospital of Zaozhuang Mining Group,Zaozhuang 277519,China 【Abstract】 Objective To observe the therapeutic effect and safety of progesterone treatments of coal worker’s peumoconiosis（CWP） cor pulmonale.Methods 96 patients of CWP cor pulmonale were randomly divided into three groups: Progesterone treatment group and foundation treatment group both in which patients complicated by respiratory failure and progesterone treatment group that patients without respiratory failure,then comparing their blood gas analysis and pulmonary function under different pneumoconiosis stage that before and after treatment, meanwhile observe their adverse reactions.Results After progesterone treatment,the PaO2 increased significantly（P0.05） in patients without respiratory failure group.In addition the blood gas analysis and pulmonary function of pneumoconiosis patients underⅠ,Ⅱ period were significantly improve than those in Ⅲ period after treated with progesterone.Conclusion It was safe and effective that treating CWP cor pulmonale with progesterone,meanwhile it could significantly improve the blood gas analysis and pulmonary function of CWP cor pulmonale patients complicated by respiratory failure,and the therapeutic effects on pneumoconiosis patients underⅠ,Ⅱ period were better than those in Ⅲ period. 【Key words】 Peumoconiosis; Progesterone; Cor pulmonale; Respiratory failure 黄体酮是临床常用孕激素类药物之一，国内外研究已证实其对通气的刺激作用［1～5］，但作用机制尚不明确。目前尚未见黄体酮治疗煤工尘肺（coal worker’s peumoconiosis，CWP）肺心病疗效的评价报道。本研究