观察鲑降钙素治疗老年骨质疏松所致骨痛疗效及对骨密度影响.docVIP

观察鲑降钙素治疗老年骨质疏松所致骨痛疗效及对骨密度影响 观察鲑降钙素治疗老年骨质疏松所致骨痛的疗效和对骨密度的影响 本文来源：论文 / 冯俊芳 陈慧芳 曾金明 李佳 【摘要】 目的 观察鲑降钙素治疗老年骨质疏松所致骨痛的疗效和对骨密度的影响。方法 将120例骨质疏松患者随机分为对照组和观察组各60例，均给予口服阿仑膦酸钠和碳酸钙d3，治疗组同时加用鲑降钙素，均连续应用3个月，治疗前后经骨密度(双能x线)检测腰椎bmd变化及根据临床症状评价疗效。结果 治疗后检测两组l2、l3、l4骨密度和治疗前比较显著升高，和治疗前差异有显著性 (plt;0.05)。两组临床疗效比较，观察组总有效率明显高于对照组。治疗后多数患者骨关节疼痛明显好转，总有效率91.67%。治疗过程中未发生明显不良反应。结论 使用鲑降钙素联合阿仑膦酸钠治疗骨质疏松能明显提高骨密度，能在一定程度上抑制骨丢失,增加骨密度，缓解骨质疏松引的疼痛，改善老年骨质疏松患者的生活质量。 【关键词】 鲑降钙素;骨质疏松症;骨痛;骨密度 　　abstract objective to evaluate the salmon calcitonin treatment effect of ostealgia due to osteoporosis and the impact on bone mineral density.methods 120 patients with osteoporosis were randomly divided into control and treatment group 60 patients were given oral alendronate sodium and carbonic acid calcium d3，the treatment group were added salmon calcitonin，are continuous application for 3 months before and after treatment.the bone mineral density (dual energy x ray) and the detection of changes in lumbar spine bmd were evaluated based on clinical symptoms.results after treatment，l2，l3，l4 bone mineral density was significantly higher before treatment，with significant difference (plt;0.05).comparison of clinical efficacy，the efficiency of the treatment group was significantly higher.after treatment，most patients significantly improved in bone and joint pain，and the total efficiency was 91.67%.the course of treatment has no obvious adverse reactions.conclusion joint use of salmon calcitonin treatment of osteoporosis，alendronate significantly increased bone mineral density，can be suppressed to some extent，bone loss，increase bone density，osteoporosis cited ease pain and improve the lives of elderly patients with osteoporosis quality. 　　key words salmon calcitonin;osteoporosis;ostealgia;bone mineral density 　　目前我国整个人口比例出现了明显老龄化，随着老年人人口数量的大量增加，相应出现了各种各样的老年疾病，而在这些老年人中患骨质疏松症的患者日益增多，原发性骨质疏松症是以骨量减少，骨的显微结构改变，骨的脆性增加，易于引起骨折为特征的一种疾病。病因尚不完全清楚，一般认为和老年退行性改变有关。所有患者均存在腰背痛及全身骨痛。而这些疼痛则明显降低了这些老年患者的生活质量。关于此病的临床治疗主要予抗骨吸收治疗，延缓骨密度下降等对症处理。自2010年1月-