a valepotriate fraction of valeriana glechomifolia shows sedative and anxiolytic properties and impairs recognition but not aversive memory in micevalepotriate一部分缬草glechomifolia显示镇静和抗焦虑的性质和损害识别而不是厌恶老鼠的记忆力.pdfVIP

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a valepotriate fraction of valeriana glechomifolia shows sedative and anxiolytic properties and impairs recognition but not aversive memory in micevalepotriate一部分缬草glechomifolia显示镇静和抗焦虑的性质和损害识别而不是厌恶老鼠的记忆力.pdf

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a valepotriate fraction of valeriana glechomifolia shows sedative and anxiolytic properties and impairs recognition but not aversive memory in micevalepotriate一部分缬草glechomifolia显示镇静和抗焦虑的性质和损害识别而不是厌恶老鼠的记忆力

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 720853, 7 pages doi:10.1093/ecam/nep232 Original Article A Valepotriate Fraction of Valeriana glechomifolia Shows Sedative and Anxiolytic Properties and Impairs Recognition But Not Aversive Memory in Mice Natasha Maurmann,1, 2 Gustavo Kellermann Reolon,1, 2 Sandra Beatriz Rech,3 Arthur Germano Fett-Neto,1 and Rafael Roesler1, 2 1 Graduate Program in Cellular and Molecular Biology, Center for Biotechnology, Federal University of Rio Grande do Sul, 91501 970 Porto Alegre, RS, Brazil 2 Laboratory of Molecular Neuropharmacology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil 3 Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil Correspondence should be addressed to Natasha Maurmann, natasha.maurmann@ufrgs.br Received 14 August 2009; Accepted 1 December 2009 Copyright © 2011 Natasha Maurmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Plants of the genus Valeriana (Valerianaceae) are used in traditional medicine as a mild sedative, antispasmodic and tranquilizer in many countries. This study was undertaken to explore the neurobehavioral eﬀects of systemic administration of a valepotriate extract fraction of known quantitative composition of Valeriana glechomifolia (endemic of southern Brazil) in mice. Adult animals −1 were treated with a s