renal heme oxygenase-1 induction with hemin augments renal hemodynamics, renal autoregulation, and excretory function肾血红素oxygenase-1感应与氯高铁血红素增加肾血流动力学,肾自动调整,排泄功能.pdf

Hindawi Publishing Corporation International Journal of Hypertension Volume 2012, Article ID 189512, 8 pages doi:10.1155/2012/189512 Research Article Renal Heme Oxygenase-1 Induction with Hemin Augments Renal Hemodynamics, Renal Autoregulation, and Excretory Function Fady T. Botros,1 Leszek Dobrowolski,1, 2 and L. Gabriel Navar1 1 Department of Physiology, Hypertension and Renal Center, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL39, New Orleans, LA 70112, USA 2 Laboratory of Renal and Body Fluid Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, A. Pawi nskiego 5 Street, 02-106 Warsaw, Poland ´ Correspondence should be addressed to Fady T. Botros, fbotros@ Received 13 August 2011; Accepted 28 September 2011 Academic Editor: David E. Stec Copyright © 2012 Fady T. Botros et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Heme oxygenases (HO-1; HO-2) catalyze conversion of heme to free iron, carbon monoxide, and biliverdin/bilirubin. To determine the effects of renal HO-1 induction on blood pressure and renal function, normal control rats (n = 7) and hemin- treated rats (n = 6) were studied. Renal clearance studies were performed on anesthetized rats to assess renal function; renal blood flow (RBF) was measured using a transonic flow probe placed around the left renal artery. Hemin treatment significantly induced renal HO-1. Mean arterial pressure and heart rate were not different (115 ± 5 mmHg versus 112 ± 4 mmHg and 331 ± 16 versus 346 ± 10 bpm). However, RBF was significantly higher (9.1 ± 0.8 versus 7.0 ± 0.5 mL/min/g,