robust semiparametric optimal testing procedure for multiple normal means健壮的半参数最优测试过程为多个正常手段.pdf

Hindawi Publishing Corporation Journal of Probability and Statistics Volume 2012, Article ID 913560, 14 pages doi:10.1155/2012/913560 Research Article Robust Semiparametric Optimal Testing Procedure for Multiple Normal Means Peng Liu1 and Chong Wang1, 2 1 Department of Statistics, Iowa State University, Ames, IA 50011, USA 2 Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA 50011, USA Correspondence should be addressed to Peng Liu, pliu@ Received 27 March 2012; Accepted 10 May 2012 Academic Editor: Yongzhao Shao Copyright q 2012 P. Liu and C. Wang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In high-dimensional gene expression experiments such as microarray and RNA-seq experiments, the number of measured variables is huge while the number of replicates is small. As a consequence, hypothesis testing is challenging because the power of tests can be very low after controlling multiple testing error. Optimal testing procedures with high average power while controlling false discovery rate are preferred. Many methods were constructed to achieve high power through borrowing information across genes. Some of these methods can be shown to achieve the optimal average power across genes, but only under a normal assumption of alternative means. However, the assumption of a normal distribution is likely violated in practice. In this paper, we propose a novel semiparametric optimal testing SPOT procedure for high- dimensional data with small sample size. Our p