消旋卡多曲治疗小儿急性水样腹泻疗效.docVIP

消旋卡多曲治疗小儿急性水样腹泻疗效【摘要】目的：观察消旋卡多曲治疗小儿急性水样腹泻的临床疗效，为小儿急性水样腹泻临床用药治疗提供指导。方法：我院在2011年1月至2012年6月共收治109例急性水样腹泻患儿，将其视为作为本次实验的研究对象，将所有患儿随机分为2组，即对照组（n=54）和治疗组（n=55）；2组患儿均给予合理饮食、抗病毒治疗、口服补液或者静脉补液以及对症支持治疗等常规治疗方案，对照组患儿在常规治疗方案的基础上给予双歧杆菌乳杆菌嗜热链球菌三联活菌片，口服，＞1岁1片/d，2次/d，1-3岁2片/次，2次/d，另加双八面蒙脱石散剂，口服，＞1岁，1袋/d，分3次服下，1-3岁2-3袋/d，分3次服下，首次服用剂量依前述标准加倍；治疗组患儿在常规治疗方案的基础上给予消旋卡多曲，口服，1.5 mg/kg，3次/d；对比分析2组患儿的临床效果差异，观察不良反应情况。结果：（1）临床效果：治疗组患儿显效29例（52.7%，29/55）、有效24例（43.6%，24/55）、无效2例（3.6%，2/55）、总有效53例（96.4%，53/55），对照组患儿显效16例（29.6%，16/54）、有效20例（37.0%，20/54）、无效18例（33.3%，18/54）、总有效36例（66.7%），2组患儿之间总有效率差异明显，具有统计学意义（P＜0.05）；（2）不良反应：对照组患儿中3例患儿出现呕吐，1例患儿出现便秘，停药2 d之后自动消失；治疗患儿未出现任何明显不良反应。结论：消旋卡多曲治疗小儿急性水样腹泻具有优秀的临床表现，用药安全，成本经济，建议临床推广使用。 【关键词】消旋卡多曲；小儿急性水样腹泻；疗效观察 Racecadotril in treatment of children with acute watery diarrhea curative effect TANG Yong-ying(Department of Pediatrics, the first People?s hospital of suining City, Sichuan 629000) [Abstract] Objective : To observe the effect of racecadotril in treatment of children with acute watery diarrhea curative effect, for children with acute watery diarrhea in clinical drug treatment to provide guidance. Methods: in our hospital in 2011 January to 2012 June were treated 109 cases of acute watery diarrhea, be considered as the object of study, all the patients were divided into 2 groups, control group ( n=54 ) and treatment group ( n=55 ); the 2 groups were given a reasonable diet, the anti-virus therapy, oral rehydration or intravenous rehydration and symptomatic and supportive therapy and other conventional treatment options, patients in the control group in the conventional treatment regimens based on given Bifidobacterium lactis Streptococcus thermophilus triple viable tablets, oral, 1 years old 1 /d, 2 /d, 1-3 years 2 / time, 2 /d, plus double eight montmorillonite powder, oral, 1 years old, 1 bags of /d, divided into 3 suits, 1-3 2-3 /d bag, cent is taken 3 times, the first dose in the standard double; the treatment group was treated with routine treat