炎琥宁粉针及地塞米松注射液在三种输液中配伍稳定性考察.docVIP

炎琥宁粉针及地塞米松注射液在三种输液中配伍稳定性考察[摘要] 目的:考察注射用炎琥宁粉针与地塞米松注射液在不同输液中的稳定性。方法:采用紫外分光光度计、精密pH计等方法,模拟临床用药,考察炎琥宁与常用抗敏药地塞米松注射液配伍后0、1、2、4、6 h时在3种不同输液中的含量、外观性状、紫外光谱及pH值变化。结果:实验过程中,配伍液外观、pH值及含量均无明显变化。结论:注射用炎琥宁与地塞米松注射液在3种输液中配伍后在室温(25℃)下6 h内稳定,可供临床使用。 [关键词] 炎琥宁粉针;地塞米松;稳定性;输液 [中图分类号] R943[文献标识码]A [文章编号]1673-7210(2010)04(a)-097-03 Study on the compatible stability of Yanhuning Powder for Injection and Dexamethasone Injection in three infusions HUANG Xiaojun, LI Xing, GAN Meichan (The People’s Hospital in Jiangmen City, Jiangmen 529020, China) [Abstract] Objective:To Study the stability of Yanhuning Powder for Injection and Dexamethasone Injection in various infusion. Methods: Using UV spectrophotometer, precision pH meter and other methods, we simulated the clinical use of drugs, to determine the content, appearance properties, UV spectra and pH of compatibility ,Yanhuning Powder and Dexamethasone Injection which were commonly used as anti-allergy drug, after 0, 1, 2, 4, 6 h in three different solution. Results: The appearance, pH and content of compatibility had no significant changes. Conclusion: Yanhuning Powder and Dexamethasone Injection are stable in three kinds of solution at room temperature (25℃) within 6 h. [Key words] Yanhuning Powder; Dexamethasone; Stability; Infusion 注射用炎琥宁(1,4-脱羟-11,12-二脱氢穿心莲内酯-3,9-二琥珀酸半酯钾钠盐)是由穿心莲内酯与琥珀酸酐经半合成后得到的有着明确化学单体的中药西制产品,分子量为610.68,具清热解毒作用,主要用于病毒性肺炎和病毒性上呼吸道感染。近年来,炎琥宁在临床上的广泛应用[1],统计了我院门诊药房1个月的处方,其中使用炎琥宁粉针的处方占总处方数的6.3%,使用频率较大,而使用5%葡萄糖注射液作为溶媒的占80.6%。而随着炎琥宁粉针在临床应用上日益增多,也出现了不少不良反应的案例[2-3]。地塞米松是目前临床应用广泛的抗药物过敏的药品,处方中常用其与炎琥宁粉针剂配伍使用以减少炎琥宁所致的过敏反应。本课题拟将注射用炎琥宁与常用抗敏药地塞米松注射液配伍,观察其在3种常用输液中配伍稳定性,为临床配伍用药[4-6]提供依据。 1 仪器与试药 1.1 仪器 UV-260分光光度计(日本岛津);精密pH计。 1.2 药品 注射用炎琥宁80 mg/瓶(批号重庆药友药业有限公司);5%葡萄糖注射液500 ml(批号:090823026,六安华源制药有限公司);0.9%氯化钠注射液500 ml(批号:090719046,六安华源制药有限公司);5%葡萄糖氯化钠注射液500 ml(批号:0908130,湖南康源制药有限公司);地塞米松注射液1 ml∶5 mg(批号:090808,白云山天心制药有限公司)。 2 方法与结果 2.1 波长的选取 取注射用炎琥宁粉针80 mg,注射用水溶解,转移至250 ml量瓶中,并用注射用水稀释至刻