biases and power for groups comparison on subjective health measurements偏见和主观健康组比较测量.pdfVIP

Biases and Power for Groups Comparison on Subjective Health Measurements 1,2 1 1 1 3 Jean-Franc¸ois Hamel *, Jean-Benoit Hardouin , Tanguy Le Neel , Gildas Kubis , Yves Roquelaure , ´ ´ 1 Veronique Sebille 1 EA 4275: Biostatistics, Clinical Research and Subjective Measurements in Health Sciences, Faculty of Pharmaceutical Sciences, University of Nantes, Nantes, France, 2 Methodology and Biostatistics Unit, University of Angers, Angers, France, 3 Laboratory of Ergonomics and Epidemiology in Health at Work, University of Angers, Angers, France Abstract Subjective health measurements are increasingly used in clinical research, particularly for patient groups comparisons. Two main types of analytical strategies can be used for such data: so-called classical test theory (CTT), relying on observed scores and models coming from Item Response Theory (IRT) relying on a response model relating the items responses to a latent parameter, often called latent trait. Whether IRT or CTT would be the most appropriate method to compare two independent groups of patients on a patient reported outcomes measurement remains unknown and was investigated using simulations. For CTT-based analyses, groups comparison was performed using t-test on the scores. For IRT-based analyses, several methods were compared, according to whether the Rasch model was considered with random effects or with fixed effects, and the group effect was included as a covariate or not. Individual latent traits values were estimated using either a deterministic method or by stochastic approaches. Latent traits were then compared with a t-test. Finally, a two-steps metho