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cellular host responses to gliomas神经胶质瘤细胞宿主反应
Cellular Host Responses to Gliomas
1 . 3 . 1 1 1
Joseph Najbauer * , Peter C. Huszthy * , Michael E. Barish , Elizabeth Garcia , Marianne Z. Metz ,
1 1 1 3 1
Sarah M. Myers , Margarita Gutova , Richard T. Frank , Hrvoje Miletic , Stephen E. Kendall ,
Carlotta A. Glackin1, Rolf Bjerkvig3,4, Karen S. Aboody1,2
1 Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America, 2 Division of
Neurosurgery, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America, 3 NorLux Neuro-Oncology, Department
´
of Biomedicine, University of Bergen, Bergen, Norway, 4 NorLux Neuro-Oncology, Centre de Recherche Public de la Sante, Luxembourg, Luxembourg
Abstract
Background: Glioblastoma multiforme (GBM) is the most aggressive type of malignant primary brain tumors in adults.
Molecular and genetic analysis has advanced our understanding of glioma biology, however mapping the cellular
composition of the tumor microenvironment is crucial for understanding the pathology of this dreaded brain cancer. In this
study we identified major cell populations attracted by glioma using orthotopic rodent models of human glioma
xenografts. Marker-specific, anatomical and morphological analyses revealed a robust influx of host cells into the main
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