原创力文档cellular expression, trafficking, and function of two isoforms of human ulbp5raet1g细胞表达、贩运和函数的两个人类ulbp5raet1g的亚型.pdfVIP
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cellular expression, trafficking, and function of two isoforms of human ulbp5raet1g细胞表达、贩运和函数的两个人类ulbp5raet1g的亚型
Cellular Expression, Trafficking, and Function of Two
Isoforms of Human ULBP5/RAET1G
1,5 2 2 ´ ´ 1 1
Robert A. Eagle *, Gillian Flack , Anthony Warford , Jesus Martınez-Borra , Insiya Jafferji , James A.
Traherne1, Maki Ohashi 1, Louise H. Boyle 1, Alexander D. Barrow 1, Sophie Caillat-Zucman3, Neil T.
Young4, John Trowsdale 1
1 Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrookes Hospital, Cambridge, United Kingdom, 2 Atlas of Protein Expression Group,
ˆ
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom, 3 INSERM U561 AVENIR Team, Hopital St-Vincent de Paul,
Paris, France, 4 Department of Pathology, University of Cambridge, Cambridge, United Kingdom, 5 California Institute of Technology, MC170-25, Pasadena, California,
United States of America
Abstract
Background: The activating immunoreceptor NKG2D is expressed on Natural Killer (NK) cells and subsets of T cells. NKG2D
contributes to anti-tumour and anti-viral immune responses in vitro and in vivo. The ligands for NKG2D in humans are
diverse proteins of the MIC and ULBP/RAET families that are upregulated on the surface of virally infected cells and tumours.
Two splicing variants of ULBP5/RAET1G have been cloned previously, but not extensively characterised.
Methodology/Principal Findings: We pursue a number of approaches to characterise the expression, trafficking, and function
of the two isoforms of ULBP5/RAET1G. We show that both transcripts
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