chronic myeloid leukemia patients in prolonged remission following interferon-α monotherapy have distinct cytokine and oligoclonal lymphocyte profile慢性骨髓性白血病患者在长期缓解interferon-α单一疗法具有不同的细胞因子和寡克隆淋巴细胞.pdfVIP

Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-a Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile Anna Kreutzman1., Peter Rohon 1,2., Edgar Faber2, Karel Indrak2, Vesa Juvonen3, Veli Kairisto3, ´ 4 5 ´ ´ 6 1 7 Jaroslava Voglova , Marjatta Sinisalo , Emı lia Flochova , Jukka Vakkila , Petteri Arstila , Kimmo Porkka1,8, Satu Mustjoki 1,8,9* 1 Hematology Research Unit, Biomedicum Helsinki, Helsinki University Central Hospital (HUCH), Helsinki, Finland, 2 Department of Hemato-Oncology, University Hospital Olomouc, Olomouc, Czech Republic, 3 Department of Clinical Chemistry and TYKSLAB, Turku University Central Hospital, Turku, Finland, 4 2nd Department of Internal ´ ´ ´ ´ Medicine, Clinical Hematology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic, 5 Department of Internal Medicine, Tampere University Hospital, Tampere, Finland, 6 Department of Hematology and Transfusiology, University Hospital Martin, Martin, Slovak Republic, 7 Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland, 8 Division of Hematology, Department of Medicine, Helsinki University Central Hospital (HUCH), Helsinki, Finland, 9 Laboratory of Hematology, Department of Clinical Chemistry, Helsinki University Central Hospital (HUCH), Helsinki, Finland Abstract Before the era of tyrosine kinase inhibitors (TKIs), interferon-alpha (IFN-a) was the treatment of choice in chronic myeloid leukemia (CML). Curiously, some IFN-a treated patients were able to discontinue therapy without disease p