deletion of cdkal1 affects high-fat diet–induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes删除cdkal1影响脂肪食源性脂肪堆积及分子生物学在小鼠胰岛素分泌,指示与糖尿病之间的关系.pdfVIP

Deletion of CDKAL1 Affects High-Fat Diet–Induced Fat Accumulation and Glucose-Stimulated Insulin Secretion in Mice, Indicating Relevance to Diabetes 1. 1. 2 2 2 Tadashi Okamura , Rieko Yanobu-Takanashi , Fumihiko Takeuchi , Masato Isono , Koichi Akiyama , 1 1 2 3 4,5 Yukiko Shimizu , Motohito Goto , Yi-Qiang Liang , Ken Yamamoto , Tomohiro Katsuya , 6 7 8 5,9 10 Akihiro Fujioka , Keizo Ohnaka , Ryoichi Takayanagi , Toshio Ogihara , Yukio Yamori , Norihiro Kato2* 1 Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan, 2 Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan, 3 Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, 4 Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan, 5 Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan, 6 Amagasaki Health Medical Foundation, Amagasaki Japan, 7 Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 8 Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 9 Morinomiya University of Medical Sciences, Osaka, Japan, 10 Mukogawa Women’s Un