dioscorea alata attenuates renal interstitial cellular fibrosis by regulating smad- and epithelial-mesenchymal transition signaling pathways薯蓣属alata变弱肾间质细胞纤维化通过调节smad epithelial-mesenchymal过渡信号通路.pdfVIP

Dioscorea alata Attenuates Renal Interstitial Cellular Fibrosis by Regulating Smad- and Epithelial- Mesenchymal Transition Signaling Pathways 1 2 3 4 1 5 Shu-Fen Liu , Shan-Yu Chang , Tao-Chen Lee , Lea-Yea Chuang , Jinn-Yuh Guh , Chien-Ya Hung , 2 6 7 2 2,8 Tsung-Jen Hung , Yu-Ju Hung , Po-Yi Chen , Pei-fang Hsieh , Yu-Lin Yang * 1 Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, 2 Department of Graduate Institute of Biomedical Science, Chung Hwa University of Medical Technology, Tainan, Taiwan, 3 Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, 4 Department of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, 5 Department of Food Nutrition Chung Hwa University of Medical Technology, Tainan, Taiwan, 6 Department of Public Health, National Taiwan University, Taipei, Taiwan, 7 Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan, 8 Department of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology, Tainan, Taiwan Abstract Renal interstitial fibrosis is characterized by increased extracellular matrix (ECM) synthesis. Epithelial-mesenchymal transition (EMT) in kidneys is driven by regulated expression of fibrogenic cytokines such as transforming growth factor-beta (TGF-b). Yam, or Dioscorea alata (DA) is an important herb in Chinese medicine widely used for the treatment of clinical diabetes mellitus. However, the fibrosis regulatory effect of DA is unclear. Thus, we examined TGF-b signaling mechanisms against EMT in rat fibroblast