diabetic hdl is dysfunctional in stimulating endothelial cell migration and proliferation due to down regulation of sr-bi expression糖尿病hdl功能失调在刺激内皮细胞迁移和增殖由于sr-bi表达的调节.pdfVIP

Diabetic HDL Is Dysfunctional in Stimulating Endothelial Cell Migration and Proliferation Due to Down Regulation of SR-BI Expression 1,2,3 1,3 1,3 4 5 4 1,3 Bing Pan , Yijing Ma , Hui Ren , Yubin He , Yongyu Wang , Xiaofeng Lv , Donghui Liu , 1,3 1,3 1,3 6 6 7 Liang Ji , Baoqi Yu , Yuhui Wang , Y. Eugene Chen , Subramaniam Pennathur , Jonathan D. Smith , George Liu1,3*, Lemin Zheng1,2,3* 1The Institute of Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, 2 Institute of Systems Biomedicine, School of Basic Medical Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beijing, China, 3 Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Health Science Center, Beij ing, China, 4 The Military General Hospital of Beij ing, Beij ing, China, 5 Department of Pathology, Shantou University Medical College, Shantou, Guangdong, China, 6 Department of Medicine, University of Michigan, Ann Arbor, Michigan, United States of America, 7 Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio, United States of America Abstract Background: Diabetic HDL had diminished capacity to stimulate endothelial cell (EC) proliferation, migration, an