disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity生长激素受体的破坏阻止热量限制提高胰岛素的行动和长寿.pdfVIP

Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity 1,2 3 1 1,4 1,5 Michael S. Bonkowski , Fernando P. Dominici , Oge Arum , Juliana S. Rocha , Khalid A. Al Regaiey , 1 1 1 1 6 Reyhan Westbrook , Adam Spong , Jacob Panici , Michal M. Masternak , John J. Kopchick , Andrzej Bartke1,2* 1 Department of Internal Medicine – Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America, 2 Department of ´ ´ Pharmacology, and Physiology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America, 3 Instituto de Quımica y Fisicoquımica ´ ´ Biologicas (IQUIFIB), Facultad de Farmacia y Bioquımica, Universidad de Buenos Aires, Buenos Aires, Argentina, 4 Department of Morphology, Laboratory of Cellular Biology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil, 5 Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, 6 Department of Biomedical Sciences, Edison Biotechnology Institute, Ohio University, Athens, Ohio, United States of America Abstract Most mutations that delay aging and prolong lifespan in the mouse are related to somatotropic and/or insulin si