dopamine signalling in mushroom bodies regulates temperature-preference behaviour in drosophila蘑菇体的多巴胺信号调节temperature-preference果蝇的行为.pdfVIP

Dopamine Signalling in Mushroom Bodies Regulates Temperature-Preference Behaviour in Drosophila 1 2 1 1 1 Sunhoe Bang , Seogang Hyun , Sung-Tae Hong , Jongkyun Kang , Kyunghwa Jeong , Joong-Jean 3 1 4,5,6 Park , Joonho Choe *, Jongkyeong Chung * 1 Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon, Korea, 2 School of Biological Sciences, Chung-Ang University, Seoul, Korea, 3 Department of Physiology, College of Medicine, Korea University, Seoul, Korea, 4 National Creative Research Initiatives Center for Energy Homeostasis Regulation, Seoul National University, Seoul, Korea, 5 Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea, 6 School of Biological Sciences, Seoul National University, Seoul, Korea Abstract The ability to respond to environmental temperature variation is essential for survival in animals. Flies show robust temperature-preference behaviour (TPB) to find optimal temperatures. Recently, we have shown that Drosophila mushroom body (MB) functions as a center controlling TPB. However, neuromodulators that control the TPB in MB remain unknown. To identify the functions of dopamine in TPB, we have conducted various genetic studies in Drosophila. Inhibition of dopamine biosynthesis by genetic mutations or treatment with chemical inhibitors caused flies to prefer temperatures colder than normal. We also found that dopaminergic neurons are involved in TPB regulation, as the targeted inactivation of dopaminergic neurons by expression of a potassium channel (Kir2.1) induced flies with