effect of birth year on birth weight and obesity in adulthood comparison between subjects born prior to and during the great depression in iceland出生年对出生体重和肥胖的影响在成年后对比对象出生之前,在大萧条期间在冰岛.pdfVIP

Effect of Birth Year on Birth Weight and Obesity in Adulthood: Comparison between Subjects Born Prior to and during the Great Depression in Iceland 1 1 1 2,3 Cindy Mari Imai *, Thorhallur Ingi Halldorsson , Ingibjorg Gunnarsdottir , Vilmundur Gudnason , 2,3 4 1 1 Thor Aspelund , Gudmundur Jonsson , Bryndis Eva Birgisdottir , Inga Thorsdottir 1 Unit for Nutrition Research, Landspitali University Hospital and Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, Reykjavik, Iceland, 2 Icelandic Heart Assocation, Kopavogur, Iceland, 3 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland, 4 Faculty of Humanities, Department of History and Philosophy, University of Iceland, Reykjavik, Iceland Abstract Background: Many epidemiological studies have linked small size at birth to adverse adult health outcomes but the relative influence of environmental exposures is less well established. Methods: The authors investigated the impact of prenatal environmental exposure by comparing 2750 participants born before (1925–1929) and during (1930–1934) the Great Depression in Reykjavik, Iceland. Calendar year served as proxy for environmental effects. Anthropometric measurements at birth and school-age (8–13 years) were collected from national registries. Participants were medically examined as adults (33–65 years). Results: Mean birth weight, adjusted for maternal age and parity, decreased by 97 g (95% confidence interval (CI): 39, 156) for men and 70 g (95% CI: 11, 129) for women fr