role of medicinal plants and natural products on osteoporotic fracture healing药用植物和天然产物在骨质疏松性骨折愈合.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 714512, 7 pages doi:10.1155/2012/714512 Review Article Role of Medicinal Plants and Natural Products on Osteoporotic Fracture Healing Mohd Azri Abd Jalil,1, 2 Ahmad Nazrun Shuid,1 and Norliza Muhammad1 1 Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur, Malaysia 2 Department of Basic Medical Science, Kulliyyah of Nursing, International Islamic University Malaysia, Level 2, Jalan Hospital Campus, P.O. Box 141, Pahang Darul Makmur, 25710 Kuantan, Malaysia Correspondence should be addressed to Norliza Muhammad, norliza ssp@ Received 13 June 2012; Accepted 17 July 2012 Academic Editor: Ima Nirwana Soelaiman Copyright © 2012 Mohd Azri Abd Jalil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Popularly known as “the silent disease” since early symptoms are usually absent, osteoporosis causes progressive bone loss, which renders the bones susceptible to fractures. Bone fracture healing is a complex process consisting of four overlapping phases— hematoma formation, inflammation, repair, and remodeling. The traditional use of natural products in bone fractures means that phytochemicals can be developed as potential therapy for reducing fracture healing period. Located closely near the equator, Malaysia has one of the world’s largest rainforests, which are homes to exotic herbs and medicinal plants. Eurycoma longifolia (Tongkat Ali), Labisia pumila (Kacip Fatimah), and Piper sarmentosum (Kaduk) are some examples of