self-organization of motor-propelled cytoskeletal filaments at topographically defined borders自组织的motor-propelled细胞骨架纤维从地形上定义的边界.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 647265, 10 pages doi:10.1155/2012/647265 Research Article Self-Organization of Motor-Propelled Cytoskeletal Filaments at Topographically Defined Borders ˚ 1 2 1 2 Alf Mansson, Richard Bunk, Mark Sundberg, and Lars Montelius 1 School of Natural Sciences, Linnaeus University, 391 82 Kalmar, Sweden 2 Division of Solid State Physics and The Nanometer Structure Consortium, Lund University, Box 118, S221 00 Lund, Sweden ˚ Correspondence should be addressed to Alf Mansson, alf.mansson@lnu.se Received 31 August 2011; Accepted 7 January 2012 Academic Editor: P. Bryant Chase ˚ Copyright © 2012 Alf Mansson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Self-organization phenomena are of critical importance in living organisms and of great interest to exploit in nanotechnology. Here we describe in vitro self-organization of molecular motor-propelled actin filaments, manifested as a tendency of the filaments to accumulate in high density close to topographically defined edges on nano- and microstructured surfaces. We hypothesized that this “edge-tracing” effect either (1) results from increased motor density along the guiding edges or (2) is a direct consequence of the asymmetric constraints on stochastic changes in filament sliding direction imposed by the edges. The latter hypothesis is well captured by a mo