statistical methods for mapping multiple qtl统计方法映射多个qtl.pdfVIP

Hindawi Publishing Corporation International Journal of Plant Genomics Volume 2008, Article ID 286561, 8 pages doi:10.1155/2008/286561 Review Article Statistical Methods for Mapping Multiple QTL Wei Zou1, 2 and Zhao-Bang Zeng1, 2, 3 1 Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27695, USA 2 Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA 3 Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA Correspondence should be addressed to Zhao-Bang Zeng, zeng@ Received 17 December 2007; Accepted 29 April 2008 Recommended by Shizhong Xu Since Lander and Botstein proposed the interval mapping method for QTL mapping data analysis in 1989, tremendous progress has been made in the last many years to advance new and powerful statistical methods for QTL analysis. Recent research progress has been focused on statistical methods and issues for mapping multiple QTL together. In this article, we review this progress. We focus the discussion on the statistical methods for mapping multiple QTL by maximum likelihood and Bayesian methods and also on determining appropriate thresholds for the analysis. Copyright © 2008 W. Zou and Z.-B. Zeng. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. INTRODUCTION IM [5] was also proposed where phenotypic values were regressed onto expected genetic coefficients of a putative Quantitative genetics studies the variation of quantitative QTL. Mot