significant differences in markers of oxidant injury between idiopathic and bronchopulmonary-dysplasia-associated pulmonary hypertension in children显著差异的标记氧化剂伤害儿童bronchopulmonary-dysplasia-associated与特发性肺动脉高压.pdfVIP

Hindawi Publishing Corporation Pulmonary Medicine Volume 2012, Article ID 301475, 6 pages doi:10.1155/2012/301475 Clinical Study Significant Differences in Markers of Oxidant Injury between Idiopathic and Bronchopulmonary-Dysplasia-Associated Pulmonary Hypertension in Children Kimberly B. Vera,1 Donald Moore,1 English Flack,1 Michael Liske,1 and Marshall Summar2 1 Division of Cardiology, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA 2 Center for Genetic Medicine Research, Children’s National Medical Center, Washington, DC 20010, USA Correspondence should be addressed to Kimberly B. Vera, kimberly.vera@ Received 27 February 2012; Accepted 29 April 2012 Academic Editor: Serpil Erzurum Copyright © 2012 Kimberly B. Vera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. While oxidant stress is elevated in adult forms of pulmonary hypertension (PH), levels of oxidant stress in pediatric PH are unknown. The objective of this study is to measure F2 -isoprostanes, a marker of oxidant stress, in children with idiopathic pulmonary hypertension (IPH) and PH due to bronchopulmonary dysplasia (BPD). We hypothesized that F2 -isoprostanes in pediatric IPH and PH associated with BPD will be higher than in controls. Plasma F2 -isoprostanes were measured in pediatric PH patients during clinically indicated cardiac catheterization and compared with controls. F2 -Isoprostane levels were compared between IPH, PH due to BD, and controls. Five patients with IPH, 12 with PH due to BPD, and 20 control subjects were studied. Patients with IPH had statis