statistical classification strategy for proton magnetic resonance spectra of soft tissue sarcoma an exploratory study with potential clinical utility统计分类策略质子核磁共振光谱软组织肉瘤的探索性研究与潜在的临床效用.pdfVIP

Sarcoma (2002) 6, 97– 103 ORIGINAL ARTICLE Statistical classi cation strategy for proton magnetic resonance spectra of soft tissue sarcoma: an exploratory study with potential clinical utility 1 2 1 1 TEDROS BEZABEH , SAMY EL-SAYED , RAKESH PATEL , RAY L. SOMORJAI , 3 4 1 VIVIEN BRAMWELL , RITA KANDEL IAN C.P. SMITH 1Institute for Biodiagnostics, National Research Council of Canada,Winnipeg, Canada, 2CancerCare Manitoba, 3 4 Winnipeg, Canada, London Regional Cancer Centre, London, Ontario, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada 1 1 Abstract 1 Purpose: Histological grading is currently one of the best predictors of tumor behavior and outcome in soft tissue sarcoma. However, occasionally there is signi cant disagreement even among expert pathologists. An alternative method that gives more reliable and non-subjective diagnostic information is needed. The potential use of proton magnetic resonance spec- troscopy in combination with an appropriate statistical classi cation strategy was tested here in differentiating normal mesenchymal tissue from soft tissue sarcoma. Methods: Fifty-four normal and soft tissue sarcoma specimens of various histological types were obtained from 15 patients. One-dimensional proton magnetic resonance spectra were acquired at 360 MHz. Spectral data were analyzed by using both the conventional peak area ratios and a speci c statistical classi cation strategy. Result