the effect of glucagon-like peptide-2 receptor agonists on colonic anastomotic wound healing的影响glucagon-like peptide-2受体受体激动剂结肠吻合的伤口愈合.pdfVIP

Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2010, Article ID 672453, 12 pages doi:10.1155/2010/672453 Research Article The Effect of Glucagon-Like Peptide-2 Receptor Agonists on Colonic Anastomotic Wound Healing Heather A. Redstone,1 William D. Buie,1 David A. Hart,2 Laurie Wallace,3 Pamela J. Hornby,4 Sarah Sague,4 Jen J. Holst,5 and David L. Sigalet1, 3, 6 1 Division of Colorectal Surgery, Department of Surgery, Faculty of Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4 2 McCaig Institute for Bone and Joint Health, Department of Surgery, Faculty of Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4 3 Gastrointestinal Research Group and Division of Pediatric General Surgery, Department of Surgery, Faculty of Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4 4 Clinical Research and Development, Centocor Inc., Radnor, PA 19087-4557, USA 5 Panum Institute, University of Copenhagen, 1165 Copenhagen, Denmark 6 Department of Surgery, Alberta Children’s Hospital, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8 Correspondence should be addressed to David L. Sigalet, sigalet@ucalgary.ca Received 11 May 2010; Revised 23 July 2010; Accepted 29 July 2010 Academic Editor: Stanley Ashley Copyright © 2010 Heather A. Redstone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Glucagon-like peptide 2 (GLP-2) is an intestinal specific trophic hormone, with therapeutic potential; the effects on intestinal healing are unknown. We used a rat model of colonic healing, under normoxic, and stress (hypox