the effect of amifostine on submandibular gland histology after radiation辐射后amifostine对颌下腺组织学的影响.pdfVIP

Hindawi Publishing Corporation International Journal of Otolaryngology Volume 2012, Article ID 508279, 7 pages doi:10.1155/2012/508279 Clinical Study The Effect of Amifostine on Submandibular Gland Histology after Radiation Jacqueline C. Junn,1 James J. Sciubba,2 Justin A. Bishop,3 Eva Zinreich,4 Mei Tang,5 Marshall A. Levine,5 Robert A. Palermo,6 Carole Fakhry,7 Ray G. Blanco,2 John R. Saunders,2 Joseph A. Califano,2, 7 and Patrick K. Ha2, 7 1 New York Medical College, Valhalla, NY 10595, USA 2 The Milton J. Dance, Jr. Head and Neck Center, Greater Baltimore Medical Center, Baltimore, MD 21204, USA 3 Department of Pathology, Johns Hopkins University School of Medicine, MD 21205, USA 4 Department of Radiation Oncology, Greater Baltimore Medical Center, Baltimore, MD 21204, USA 5 Department of Medical Oncology, Greater Baltimore Medical Center, Baltimore, MD 21204, USA 6 Department of Pathology, Greater Baltimore Medical Center, Baltimore, MD 21204, USA 7 Division of Head and Neck Cancer Surgery, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA Correspondence should be addressed to Patrick K. Ha, pha1@ Received 28 February 2012; Revised 30 May 2012; Accepted 3 June 2012 Academic Editor: R. L. Doty Copyright © 2012 Jacqueline C. Junn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. The purpose of this study was to assess the effects of amifostine on submandibular gland histology in patients receiving chemoradiation therapy. Methods. We conducted a retrospective submandibular glan