synthesis and characterization of a new five and six membered selenoheterocyclic compounds homologues of ebselen合成和表征的新五和六元selenoheterocyclic化合物ebselen同系物.pdfVIP

Hindawi Publishing Corporation Organic Chemistry International Volume 2011, Article ID 389615, 7 pages doi:10.1155/2011/389615 Research Article Synthesis and Characterization of a New Five and Six Membered Selenoheterocyclic Compounds Homologues of Ebselen Mouslim Messali,1 Mostafa Abboudi,1 Mohamed R. Aouad,1 Nadjet Rezki,1 ´ 2 and Leon E. Christiaens 1 Department of Chemistry, Taibah University, P.O. Box 30002, Madinah, Saudi Arabia 2 Services Generaux (Faculte des Sciences) Relations Academiques et Scientifiques (Sciences), University of Liege, ´ ´ ´ ´ allee de la Chimie 3, 4000 Liege 1, Belgium ´ ` Correspondence should be addressed to Mouslim Messali, mouslim@mail.be Received 8 October 2011; Revised 18 December 2011; Accepted 27 December 2011 Academic Editor: Kirpal Bisht Copyright © 2011 Mouslim Messali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The discovery of the antioxidant activity of selenoenzyme glutathione peroxidase (GPx) has attracted growing attention in the biochemistry of selenium. Among molecules which mimic the structure of the active site of the enzyme, N -phenyl-1,2- benzisoselenazolin-3-one 1, Ebselen, exhibited useful anti-inflammatory properties. It has been extensively investigated and has undergone clinical trials as an anti-inflammatory agent. Unfortunately, Ebselen exhibits relatively poor catalytic activity, prompting attempts to design more efficacious GPx mimetics th