spines, plasticity, and cognition in alzheimers model mice刺、可塑性和认知在阿尔茨海默病模型小鼠.pdfVIP

Hindawi Publishing Corporation Neural Plasticity Volume 2012, Article ID 319836, 10 pages doi:10.1155/2012/319836 Review Article Spines, Plasticity, and Cognition in Alzheimer’s Model Mice Tara Spires-Jones1 and Shira Knafo2 1 Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA 2 Centro de Biologıa Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Cientıficas (CSIC) and ´ ´ Universidad Autonoma de Madrid, Nicolas Cabrera, 28049 Madrid, Spain ´ ´ Correspondence should be addressed to Tara Spires-Jones, tspires@ and Shira Knafo, sknafo@cbm.uam.es Received 12 September 2011; Accepted 27 October 2011 Academic Editor: Xiao-Xin Yan Copyright © 2012 T. Spires-Jones and S. Knafo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The pathological hallmarks of Alzheimer’s disease (AD)—widespread synaptic and neuronal loss and the pathological accumulation of amyloid-beta peptide (Aβ ) in senile plaques, as well as hyperphosphorylated tau in neurofibrillary tangles— have been known for many decades, but the links between AD pathology and dementia and effective therapeutic strategies remain elusive. Transgenic mice have been developed based on rare familial forms of AD and frontotemporal dementia, allowing investigators to test in detail the structural, functional, and behavioral consequences of AD-associated pathology. Here, we review work on transgenic AD mod