spontaneous eeg-functional mri in mesial temporal lobe epilepsy implications for the neural correlates of consciousness自发eeg-functional mri在内侧颞叶癫痫对意识的神经关联的影响.pdfVIP

Hindawi Publishing Corporation Epilepsy Research and Treatment Volume 2012, Article ID 385626, 10 pages doi:10.1155/2012/385626 Review Article Spontaneous EEG-Functional MRI in Mesial Temporal Lobe Epilepsy: Implications for the Neural Correlates of Consciousness Zheng Wang,1 Loretta Norton,2 R. Matthew Hutchison,3 John R. Ives,4 and Seyed M. Mirsattari2, 4, 5 1 Department of Psychology, Vanderbilt University, Nashville, 37211 TN, USA 2 Department of Psychology, University of Western Ontario, London, ON, Canada N6A 5A5 3 Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5A5 4 Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada N6A 5A5 5 Department of Medical Biophysics, University of Western Ontario, London, ON, Canada N6A 5A5 Correspondence should be addressed to Seyed M. Mirsattari, smirsat2@uwo.ca Received 20 September 2011; Revised 21 November 2011; Accepted 19 December 2011 Academic Editor: Warren T. Blume Copyright © 2012 Zheng Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The combination of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) has been shown to have great potential for providing a greater understanding of normal and diseased states in both human and animal studies. Simultaneous EEG-fMRI is particularly well suited for the study of epilepsy in that it may reveal the neurobiology of ictal and interictal epileptiform discharges and noninvasively localize epileptogenic foci. Spontaneous, coherent fluctuations of neuronal activity and