帕金森病临床特征与血脂和血尿酸水平的相关性分析.docVIP

帕金森病临床特征与血脂和血尿酸水平的相关性分析 钟 玲,雷 朋,鲁凤娇,陈亚兰,彭国光*(400016 重庆，重庆医科大学附属第一医院神经内科) [摘要] 目的 探讨帕金森病（Parkinson’s disease，PD）患者临床特征，如病情严重程度、病程、发病年龄、临床类型及每日左旋多巴等效剂量(LEDD)等，与血脂和血尿酸水平的相关性，研究其与PD患者发病风险以及病情进展预测之间的关系。方法 回顾性统计分析我院130例PD住院患者与135例非PD人群的血脂、血尿酸水平的差异性，并比较不同PD临床类型间血脂和血尿酸有无差异性，同时分析PD患者H-Y分级、病程、发病年龄及LEDD与血脂、血尿酸水平的相关性。结果 PD组与对照组相比，血尿酸、总胆固醇、甘油三酯、低密度脂蛋白及载脂蛋白A1/高密度脂蛋白值具有统计学差异（P＜0.05）；PD临床亚组中，震颤型与混合型中的低密度脂蛋白水平比较有统计学差异（P＜0.05），强直迟缓型与震颤型的载脂蛋白A1/高密度脂蛋白值有统计学差异（P＜0.05）；载脂蛋白A1/高密度脂蛋白值与PDH-Y分级呈负相关（P＜0.05），而与病程、发病年龄及LEDD无相关性（P＞0.05），血尿酸、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白与H-Y分级、病程、发病年龄及LEDD均无相关性（P＞0.05）。结论 低血脂和血尿酸水平可能是PD发病的风险因素；载脂蛋白A1/高密度脂蛋白值越低，则PD患者病情越重；PD不同临床类型间低密度脂蛋白及载脂蛋白A1/高密度脂蛋白存在差异；多巴胺能药物替代治疗不影响血脂、血尿酸水平。 [关键词]血脂；尿酸；帕金森病；临床特征 The links between Parkinson’s clinic features and serological levels of lipid and urate Zhong Ling, Lei Peng, Lu Feng-jiao, Chen Ya-lan, Peng Guo-guang. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. E-mail：penwan233@’s Disease, L-dopa equivalent daily dose and serological levels of lipid and urate. Methods Retrospectively analysised the differences of serologic levels of lipid and urate between 130 PD patients and 135 human without PD controls,and compared the difference of serologic levels between different subclinical types,and we also analysised the correlation between the levels of lipid,urate and Yahr stage,course,age at onset and LEDD of PD patients. Results Compared with the controls, the levels of serological data including urate, total cholesterol, triglycerides, Low density lipoprotein and ApoA1/HDL had statistical differences, and both the level of low-density lipoprotein cholesterol(LDL) between the tremor type and equlvalent type, and the level of ApoA1/HDL between rigidity-bradykinesia type and the tremor type had statistical diffences.Serum ApoA1/HDL was inversely related to Yahr stage. Conclusion Lower levels of serologic lipid and urate maybe the risk factors of Parkinson’s disease. The l