女性间质性膀胱炎和膀胱过度活动症的尿动力学比较研究.docVIP

女性间质性膀胱炎和膀胱过度活动症的尿动力学比较研究目的 对比研究女性间质性膀胱炎（nterstitial cystitis, IC）和膀胱过度活动（veractive bladder, OAB）患者的尿动力学特征方法 回顾性研究21IC患者和32OAB患者（均为女性）的尿动力学表现差异。结果 IC组最大尿流率（Qmax）、初始尿意容量（VFD）、最大尿意容量（MV）以及膀胱顺应性（BC）均小于OAB组( P 0. 05)， OAB组发生逼尿肌过度活跃(detrusor overactivity, DO) 25例(78.1% )IC组2例（9.5%）, 2组DO例数上亦有明显差异(P 0. 05) 。结论 女性IC患者和OAB患者在临床上表现有较大相似性，但两者的尿动力学表现在很多方面均存在差异。尿动力学检查是IC和OAB重要的鉴别方法。 间质性膀胱炎；膀胱过度活动；尿动力学；女性Urodynamic studies of interstitial cystitis and overactive bladder in women WANG Yong-quan, SONG Bo, Fang Qiang, LI Long-kun LI Wei-bing XIONG En-qing （Center of Urology, Southwest Hospital, Third Military Medical University Chongqing, 400038） Abstract：Objective To investigate the urodynamic characters of female patients with interstitial cystitis (IC) or overactive bladder (OAB). Methods According to the history, complaints and the NIDDK diagnosis standards, 21 female IC patients and 32 OAB female patients were underwent standard urodynamic examination and the results were compared between 2 groups. Results There are significant statistic difference between IC group and OAB group among following parameters(P0.05): Qmax，maximal volume at micturition desire(MV) ，volume at first desire (VFD) and bladder compliance (BC). Moreover, only 9.5 % (2/21) patients in IC group had detrusor overactivity (DO), less than that in OAB group(78.1%, 25/32)0.05）. Conclusion Several differences distinguished IC from OAB. Therefore, urodynamic examination is a valuable assistance in differential diagnosis of IC. Key words：nterstitial cystitis；veractive bladder；rodynamics；emale 间质性膀胱炎/膀胱疼痛综合征(nterstitial cystitis/ painful bladder syndrome, IC/PBS）是中青年女性较为罕见的泌尿系疾病，但近年来发病率有上升的趋势，主要临床表现为下尿路症状伴耻骨上区的疼痛。膀胱过度活动症(veractive bladder，OAB)是常见的膀胱功能障碍性疾病，发病率较高，临床表现主要是尿急、尿频或伴尿失禁。IC在临床上亦可表现为尿频尿急症状，且呈持续性发作，进行性加重的特点[1]，在症状上和OAB存在一定的相似性且种疾病在临床上均为排他性诊断，临床医师易将IC误诊为OAB或者尿路感染等疾病，延误了IC的治疗[2, 3]。但是临床上如何正确诊断IC却仍然是较为棘手的问题。尿动力学检查是评价膀胱和尿道功能重要的检查手段，可对多种下尿路功能障碍患者的诊断和治疗提供客观的依据[4]。本研究通过对比 基金项目：国家自然科学基金资助项目30700270) S