ALOX5APO基因、COX2基因及MMP9基因多态性与缺血性脑卒中相关性的研究.pdfVIP

用。 ～煳燮 实验结论：在汉族人群中，COX2-765GC基因型、COX2-1195GA基因型 以及COX2—765 195 C等位基因和COX2—1 G等位基因是缺血性脑卒中 的危险因素；C-7硒AⅢ。。单倍型和G-76sG．¨。。单倍型可增加缺血性脑卒中的发 基因和MMP9基因多态性与缺血性脑卒中可能无相关性。COX2基因和 MMP9基因间在IS中可能没有相互作用。 硕士研究生李健业(神经病学) 指导老师 张晨 教授 关键词：5脂氧合酶激活蛋白；环氧化酶2；基质金属蛋白酶9；脑卒中； 多态性 ASSoCIATIoNSTUDYBETWEENPoLyMoRPHISMSoF ALOX5AP GENE。CoX2GENEANDMMP9GENEANDISCHEMIC STROKE ABSTRACT ective：Thiswasto whether variantsintheALOX5AP Obj study explore genetic andMMP9 influencetheriskofischemic gene，COX2gene gene，would synergistically stroke． Methods：Inthis severalvariantsof wereexamined study ALOX5ApCOX2，MMP9 with302 withischemicstrokeand308contr01 amongpatients patients subjects． were studiedboth andas interactionswere polymorphisms individuallyhaplotypes．And themethodsof multifactor exploredbyusing generalized dimensionality reduction(GMDR、． Results：AassociationofCo勉．765GC O贮2，650)and genotype(adjustedCOX2 ．1195GA OR=1．565)withischemicstrokewasidentified genotype(adjusted respectively． TheCOX2—765CalleleandtheCOX2．1l95Gallelewereassociatedwith higher ischemicstroke GGandCAof765G／Cand risk(OR=2．142；1．344)．Thehaplotype 11 was in in