naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy（纳洛酮治疗缺血脑病新生儿）.docVIP

Naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy [Words] hypoxic-ischemic encephalopathy; naloxone; newborn Neonatal hypoxic-ischemic encephalopathy (hypoxic 1schemicenc- ephalopathy, HIE) in perinatal asphyxia, resulting in hypoxic-ischemic brain damage, including nerve pathophysiological changes characteristic clinical series encephalopathy performance, and in some cases can be left the degree of neurological sequelae. past three years, the hospital pediatric neonatal hypoxic-ischemic encephalopathy naloxone treatment results were satisfactory treatment results will now be reported as follows. 1 Materials and Methods 1.1 General Information 62 neonates with HIE hospital pediatric hospital in January 2007 -2009 in December, in line with the revision of the 1996 Hangzhou conference HIE diagnosis is based on clinical grading standard [1] .62 cases of HIE randomized treatment group: 32 cases, male 22 cases, 10 females; control group: 30 patients, 18 males and 12 females two sets admission time living the 30min ~ 3d. groups suffocation degree clinical indexing birth weight, gestational age, Apgar score, clinical symptoms no statistically significant differences were statistically comparable. 1.2 treatment of two groups of children admitted to hospital were given the same treatment to actively control the seizures, increased intracranial pressure, the cerebral the cells metabolic activation, etc., while the use of naloxone treatment group on the basis of the comprehensive treatment. Manalo ketone (Beijing Sihuan Pharmaceutical Factory) 0.03 ~ 0.05mg/kg intravenous injection of 10% glucose 5ml, then changed to naloxone 0.05mg/kg intravenous infusion of 10% glucose 40ml, sustained 4h, daily qd for 3 to 7 days; comparable. 1.3 clinical observation indicators before and after treatment in addition to observe the heart rate; respiratory clinical manifestations of the state of consciousness, muscle tone, primitive reflexes, convulsion