消退训练对大鼠条件性恐惧行为及海马CA1区突触超微结构的影响.docVIP

消退训练对大鼠条件性恐惧行为及海马CA1区突触超微结构的影响 张丽丽，李培培，李 敏，韦 美，彭 李（400038重庆，第三军医大学护理学院心理学教研室） [摘要] 目的:研究消退训练对大鼠条件性恐惧行为和海马CA1区突触超微结构的影响。方法：成年雄性SD大鼠40只，简单随机抽样分为正常组、消退对照组和消退组①在消退后7d和21d，消退组的消退保持成绩显著高于消退对照组（＜0.0＜0.0））②消退训练后7，消退组突触数密度显著高于消退对照组（＜0.05），与正常组之间无显著差异）③消退训练后7d和 21d，消退组突触间隙宽度显著低（＜0.0＜0.0）并且消退后21d，消退组突触间隙宽度显著低于消退对照组（＜0.05）。④与正常组相比，消退训练后7d和2d，消退组PSD厚度均显著升高（＜0.01）；且在21d，消退组PSD厚度显著高于消退对照组（＜0.05）。⑤各组之间活性区长度均无显著差异。 Extinction training on behavior and synaptic structure in hippocampal CA1 area of fear conditioned rats Zhang Lili, Li Peipei, Li Min, Wei Mei, Peng Li（Department of psychology,school of Nuring,Third Military Medical University,chongqing, 400038,China） [Abstract] Objective To explore the effects of fear extinction training on the ultrastructure of hippocamnal CA1 area in fear conditioned rats. Methods 40 male adult SD rats were randomly divided into native group, extinction control group and 24h extinction group. Extinction retention test and the changes of synaptic structure in CA1 of hippocampus were observed at 7d and 21d after fear extinction. Results ① Compared with the extinction control group, the scores of extinction retention was significantly increased (P0.01) at 7d and 21d after extinction in extinction group. There was no significant difference between extinction group and native group at 7d and 21d.② At 7d after extinction training, the synaptic density was significantly higher in extinction group than that in the extinction control group (P 0.05), and there was no difference among groups at 21d.③ Compared with native group, the width of synaptic gap was significantly lower at 7d and 21d after extinction training in extinction group (P 0.01; P 0.05). At 21d, the width of synaptic gap was significantly lower in extinction group than that in the control group (P 0.05). but there was no significant difference between the extinction control group and native group at 7d and 21d after extinction.④ Compared with native group, at 7d and 21d after extinction