三阴性乳腺癌中TopoⅡα及BRCA1表达情况与以蒽环类药物为主化疗的疗效及预后关系.pdfVIP

·中文论著摘要· IIa和BRCAl表达情况与以蒽环 三阴性乳腺癌中Topo 类药物为主化疗的疗效和预后关系 目 的 疗的疗效和预后关系 方法 选择三阴性乳腺癌患者72人(原位癌除外)，进行保乳或全切的手术，应用 关性。 结 果 异，但显著高于Top02a阴性且BRCAl阳性和两者均阴性者，生存曲线分析具有 统计学差异。 结论 对于以葸环类药物为主化疗的反应更加敏感有效，预后更好。 关键词 。 乳腺肿瘤；病理学；临床；预后 ·英文论著摘要· IIaandBRCA1 as Topoisomerase predictive expression factorsof and of response prognosis breastcancertreatedwithuvant adj anthracycline chemotherapy 工， introduction isoneofthemost aggressivedrugs Anthracycline—basedchemotherapy against to II breast bind target triple—negativecancer,anthracyclinestopoisomerasealpha,a theDNA incell moleculeof stabilize double·strand anthracycline，and breaks，resulting and tobeakind arrest isdefined of cycle apoptosis．BRCA-1 in DNA BRCAl defectivein role double—strand is important repair,and expression breast thatitis thatDNAdouble-strandbreaks cancers，SO triple-negative speculated caused