新型抗AD药物971对东莨菪碱模型大鼠地作用与影响记忆功能机制研究.pdfVIP

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新型抗AD药物971对东莨菪碱模型大鼠地作用与影响记忆功能机制研究.pdf

新型抗AD药物97I对东茛菪碱模型大鼠的作用及影响记忆功能机制研究 i ve of971013 I ami no—induced Protecteffects scope inratsanditsmoIecuIarmechanisms amnes;a Abstract acidic from novelmarine—derived extractedbrown 971,a oligosaccharide,is algae EchloniaKuromeOkam isfoundtobeapotential bydepolymerization.It candidatefor diseasewith blood therapeutic Alzheimer’S easilycrossingbrain barrierandlower studiesindicatethat971 theamnesia toxicity.Previous ameliorate ratsinduced viaitsantioxidanteffects.Into bY orderelucidatethe Afl2s-3s possibly mechanismsof971on and effect of971on learningmemory,the ratsand amnesiaonneuronal ale scopolamine—induced observed. plasticity Inthis of971on amnesiainratsisevaluated paper,effectscopolamine·induced by Morriswatermazetest.Theresultsexhibitthat with administration1 to 30一days 97 ratsattenuate memoryimpairmentbyscopolamine,indicatedby shortening escape distanceandthetimefirst for the latency,swimming reaching

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