血小板P2Y12受体基因(C34T、G52T、iT744C)多态性对冠心病患者氯吡格雷抵抗地影响.pdfVIP

sms InfluencesofP2Y12(C34T，G52T，iT744C)Polymorphi in with on ResistancePatients Clopidogrel Coronary Disease Heart Abstract thecontributionofP2Y12 Objective：Toinvestigate genetic(C34T，G52T， healthvolunteersand with inChinese iT744C)polymorphisms patients associationbetweenP2Y12 to thethe geneticpolymor— CHD，andexplore smsand resistancein withCHD． phi labortaryclopidogrel patients maleand179 66．77± Methods：548CHD female，meanage patients(369 11．33 103 underwent patients percutaneouscoronary years)，including maleand91 222 volunteers(131 interven-tion(PCI)，andhealthy 59．454-10．45 enrolledto P2Y12 female，mean identify age years)were chain C34T，G52T，iT744Cgenotypesbypolymerase withdifferent fragmentlengthpolymorphismassay．260patients genotypes receivedoral asasingle—dosetherapy(75mgday一1p．0．) lyclopidogrel for10 ofADP—induced percentage days．Inhibition plateletaggregation beforeandafter wasdetermined tre