缬沙坦对糖尿病大鼠视网膜内皮素-1表达地影响与其机制地研究.pdfVIP

-英文论文摘要· The EffectandMechanismofValsartanonthe ofEndothelin-1inrats’Retinain Expression DiabetesMellitus Objective Diabetic isoneofthesevere diabetes of retinopathy，which complicationsmellitus， tO tOthe incidenceandblind studiesshow attentions，due bringshigh hi【gh ram．Many all in andis that rolediabetic oneofthe Endothelin(ET)playimportant retinopathy vaso·active influencetheretina ofdiabetic substances，which hemodynamics this observethe oftheET·1 inthe retinopathy．Instudy，we changes proteinexpression of rats retineadiabeticwhicharetreatedthe II I by a11舀oteIlsinreceptorantagonist the mechanismof the Valsartan,reveal therapeutical suppressingrennin-angitensin inthediabetic system retinopathy． Methods 5 11 maleWistarratswitllthe between180and weredividedinto weight 2209 blankcontrol and control group，controlgroupexperimentgrouprandomly．Thegroup andthe wereinducedthe of blank experimentgroup by injectionSTZ，the peritoneal controlwas citricacidbuffer．Aftertheestablishmentofflae grouporayinjected model， was the treatedwithVal