a pilot trial on safety and efficacy of erythrocyte-mediated steroid treatment in cf patients一个试点试验erythrocyte-mediated类固醇治疗的安全性和有效性cf患者.pdfVIP

BMC Pediatrics BioMed Central Research article Open Access A pilot trial on safety and efficacy of erythrocyte-mediated steroid treatment in CF patients †1 2 1 3 V Lucidi* , AE Tozzi , S Bella and A Turchetta Address: 1Ospedale Bambino Gesù, Department of Pediatrics, Cystic Fibrosis Unit, Rome, Italy, 2Ospedale Bambino Gesù, Epidemiology Unit, Rome, Italy and 3Ospedale Bambino Gesù, Department of Pediatrics, Respiratory Fisiopathology Unit, Rome, Italy Email: V Lucidi* - lucidi@; AE Tozzi - alberto.tozzi@; S Bella - bella@; A Turchetta - turchetta@ * Corresponding author †Equal contributors Published: 24 May 2006 Received: 02 September 2005 Accepted: 24 May 2006 BMC Pediatrics 2006, 6:17 doi:10.1186/1471-2431-6-17 This article is available from: /1471-2431/6/17 © 2006 Lucidi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Chronic neutrophil inflammation of the respiratory tract tissues plays a key role in the pathogenesis and in prognosis of cystic fibrosis (CF). It is evident that an anti-inflammatory therapy represents an important step in the treatment of CF patients. Corticosteroids and ibuprofen have been proven to slow down the impair