hepatitis b virus gene mutations and clinical research（乙型肝炎病毒基因突变和临床研究）.docVIP

Hepatitis B virus gene mutations and clinical research Papers to write network: [Abstract] gene mutation occurred in the course of HBV infection, mainly distributed in the open reading frame of the L chain, the impact of the mutant HBV antigen expression to evade vaccine caused the resistance change pathological process, etc., it should lead to the clinical diagnosis, treatment, prevention, prognosis enough attention. [Keywords: of HBV DNA HBV (hepatitis B virus; (hepatitis B virus genome, mutation, drug resistance HBV genome, also known as HBV DNA, by a 3200 base pairs, to the annular part of the double-stranded DNA, is divided into a long negative-strand (the positive strand of L and short (S two strands. L chain has four open reading frame ( S, C, P, X zone. Currently, the identification of HBV genotypes A-H 8, through the analysis found that the whole sequence of HBV, the S segment heterogeneity between the different genotypes largest, the S segment type within heterogeneity least, in developed on the basis of a series of simple, accurate typing methods, to promote HBV genotype epidemiology and clinical research. The current study found that HBV and DNA virus replication method by DNA transcription into RNA and then reverse-transcribed into DNA to replicate, and therefore prone to mutation. A hepatitis B virus S gene mutation and clinical S region in the S gene, pre-S1 and pre-S2 genes encoding outer capsid protein of HBV (HBsAg, PreS1, and PreS2 antigen, namely the pre-S1 and pre-S2 antigen. If this region gene mutant (a antigen), without protective immune function although the anti-HBs in the serum, the results of HBsAg and anti-HBs can occur simultaneously in the serum, have proved, the S gene mutants can interfere with the virus particle assembly, resulting in the HBV particles decreased secretion; experimental study also found that the the splicing S gene region of the HBV genome macromolecular protein variants can le