hodgkin lymphoma cd99 gene expression of the significance of the missing（霍奇金淋巴瘤cd99基因表达意义的失踪）.docVIP

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2017-09-06 发布于浙江
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hodgkin lymphoma cd99 gene expression of the significance of the missing（霍奇金淋巴瘤cd99基因表达意义的失踪）.doc

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hodgkin lymphoma cd99 gene expression of the significance of the missing（霍奇金淋巴瘤cd99基因表达意义的失踪）

Hodgkin lymphoma CD99 gene expression of the significance of the missing The Author: Lixian Mao, Li Yan, Zhao Tong, Zhu Meigang, Zhang Jinhua Hodgkin’s lymphoma [words] [Abstract] AIM: To study the expression of CD99 of ReedSternberg cells in classical Hodgkin’s lymphoma (cHL). METHODS: Eight cHL cases were confirmed according to the new WHO pathological classification. Immunohistochemistry for CD99 was performed with SABC method, and the CD99 expression of cell lines was tested by flow cytometer. RESULTS: The positive expression of CD99 was 0% (0/8). The CD99 expression of DG75 and Jurkat cell lines was (87.3 + -0.4% and (96.8 + -0.6%, and the CD99 expression of L428 cell line was (3.8 + -0.4%. The CD99 expression of HDLM2 cell line was (66.4 + -0.3%. CONCLUSION: Downexpression of CD99 in HRS cells may be a useful index for the diagnosis of classical Hodgkin’s lymohoma . [Keywords] Hodgkin’s lymphoma; immunohistochemistry; those of CD99 gene [Abstract] Objective: To explore the classical Hodgkin lymphoma (cHL) RS cell CD99 protein expression. Methods: All eight cases of cHL new WHO classification standard diagnosis using immunohistochemical SABC method CD99 staining observed every RS cells positive expression rate of a Case, flow cytometry B lymphoma DG75 cell line T lymphoma Jurkat cells, Hodgkin’s lymphoma L428, HDLM2 cell lines CD99 protein expression results: 8 cases of cHL RS cells CD99-negative expression rate was 100% (8/8) positive (87.3 + -0.4%; the DG75 cells strains of CD99 expression in Jurkat cell lines CD99 positive expression (96.8 + -0.6%, L428 cells were CD99 positive expression (3.8 + -0.4 %, HDLM2 cell line CD99 expression (66.4 + -0.3% positive Conclusions: CD99 gene expression in Hodgkin’s lymphoma lack of reference that can be used as a diagnostic cHL. Immunohistochemistry, CD99 gene [words]-Hodgkin’s lymphoma; 0 Introduction Classical Hodgkin lymphoma (classical Hodgkin’s lymphoma, cHL) with a typical RS cells (ReedSte