原创力文档rhot1 and smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancerrhot1和smad4与淋巴结转移和整体生存在胰腺癌.pdfVIP
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rhot1 and smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancerrhot1和smad4与淋巴结转移和整体生存在胰腺癌
RhoT1 and Smad4 Are Correlated with Lymph Node
Metastasis and Overall Survival in Pancreatic Cancer
1 . 2. 1 3 3 3 3
Hua Jiang * , Chengzhi He , Shasha Geng , Haihui Sheng , Xiaoying Shen , Xiaoyan Zhang , Hang Li ,
3 2 2 2,3
Shizhang Zhu , Ximei Chen , Changqing Yang , HengJun Gao *
1 Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China, 2 Department of Gastroenterology, Institute of
Digestive Diseases, Tongji Hospital, Tongji University School of Medicine, Shanghai, China, 3 National Engineering Center for Biochip at Shanghai, Shanghai, China
Abstract
Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification
of biomarkers associated with outcome of pancreatic cancer may provide new approaches and targets for anticancer
therapy. The aim of this study is to examine the relationship between the expression of RhoT1, Smad4 and p16 and
metastasis and survival in patients with pancreatic cancer. The analysis showed that the high cytoplasmic expression levels
of RhoT1, Smad4 and p16 in pancreatic cancer tissues had significantly negative correlation with lymph node metastasis
(LNM) (P = 0.017, P = 0.032, P = 0.042, respectively). However, no significant association was observed between perineural
invasion (PNI) and the expression of above three proteins (all P.0.05). Additionally, the survival analysis showed that the
low expression levels of RhoT1 and Smad4 were significantly associated with worse surviv
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