rhythmic dynamics and synchronization via dimensionality reduction application to human gait有节奏的动力学和同步通过降维应用人类的步态.pdfVIP

Rhythmic Dynamics and Synchronization via Dimensionality Reduction: Application to Human Gait 1,2 3 1,4 2 Jie Zhang *, Kai Zhang , Jianfeng Feng , Michael Small 1 Center for Computational Systems Biology, Fudan University, Shanghai, People’s Republic of China, 2 Department of Electronic and Information Engineering, Hong Kong Polytechnic University, Hong Kong, People’s Republic of China, 3 Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, 4 Department of Computer Science and Mathematics, Warwick University, Coventry, United Kingdom Abstract Reliable characterization of locomotor dynamics of human walking is vital to understanding the neuromuscular control of human locomotion and disease diagnosis. However, the inherent oscillation and ubiquity of noise in such non-strictly periodic signals pose great challenges to current methodologies. To this end, we exploit the state-of-the-art technology in pattern recognition and, specifically, dimensionality reduction techniques, and propose to reconstruct and characterize the dynamics accurately on the cycle scale of the signal. This is achieved by deriving a low-dimensional representation of the cycles through global optimization, which effectively preserves the topology of the cycles that are embedded in a high- dimensional Euclidian space. Our approach demonstrates a clear advantage in capturing the intrinsic dynamics and probing the subtle synchronization patterns from uni/bivariate oscillatory signals over traditional methods. Application to human gait data for healthy subjects and diabetics reveals a significant difference in the dynamics of ankle movements and ankle- knee coordination, but not in knee movements. These results indicate that the i